Anti-ERCC1 Monoclonal Antibody

品牌：solarbio | 货号：K000149M

 

 

英文名称	Anti-ERCC1 Monoclonal Antibody
宿主	Mouse
别名	COFS4;RAD10;UV20
应用	WB
稀释比例	WB 1:1000.
交叉反应	Human
蛋白分子量	33kDa
Gene ID	2067
保存	Store at -20°C. Avoid freeze / thaw cycles.
储存液	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法	Affinity purification
亚型	IgG2b
免疫原	Purified recombinant human ERCC1 protein fragments expressed in E.coli.
性状	液体
Public Immunogen Range	Purified recombinant human ERCC1 protein fragments expressed in E.coli.
Subcellular Locations	Cytoplasm Nucleus
Swiss Prot	P07992
克隆号	7F6-2A10-E8
克隆类型	Monoclonal Antibody
背景资料	The product of this gene functions in the nucleotide excision repair pathway,and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin.The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4),and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion.The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks.Mutations in this gene result in cerebrooculofacioskeletal syndrome,and polymorphisms that alter expression of this gene may play a role in carcinogenesis.Multiple transcript variants encoding different isoforms have been found for this gene.The last exon of this gene overlaps with the CD3e molecule,epsilon associated protein gene on the opposite strand.[provided by RefSeq,Oct 2009]