The synucleins, including Alpha-synuclein (also designated NACP  for  nonamyloid component precursor),Beta-synuclein (also designated PNP 14 for phospho-neuroprotein 14)and Gamma-synuclein  (also designated persyn or BCSG1 for breast cancer-specific gene 1)are presynaptic protein abundant in neurons. Alpha-synuclein, a component of Alzheimer’s disease amyloid plaques, is localized to neuronal cell bodies and synapses. Coordinate  expression of  Alpha-synucleinand  Beta-synuclein may be important during hematopoetic cell differentiation. In patients with Parkinson’s disease,  a mutant form of  Alpha-synuclein  has been found and  Gamma-synuclein is associated with axonal pathology.